Università degli Studi della Campania "Luigi Vanvitelli", Piazza Luigi Miraglia 2, 80138, Naples, Italy; Mediterranea Cardiocentro, 80122, Naples, Italy. Electronic address: antonio.ceriello@hotmail.it. IRCCS MultiMedica, Via Fantoli 16/15, 20138, Milan, Italy. Università degli Studi della Campania "Luigi Vanvitelli", Piazza Luigi Miraglia 2, 80138, Naples, Italy. Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy. Department of Precision Medicine, The University of Campania "Luigi Vanvitelli", Italy. Department of Mental Health and Public Medicine, Section of Statistic, The University of Campania "Luigi Vanvitelli", Naples, Italy. Laboratory of Molecular Oncology, Gemelli Molise SpA, Campobasso, Italy. Department of Cardiovascular Medicine, Gemelli Molise SpA, Campobasso, Italy. Department of Cardiology, Hospital Cardarelli, Naples, Italy. Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy. Albert Einstein College of Medicine, USA. IRCCS MultiMedica, Via Fantoli 16/15, 20138, Milan, Italy. Electronic address: raffaele.marfella@unicampania.it. Università degli Studi della Campania "Luigi Vanvitelli", Piazza Luigi Miraglia 2, 80138, Naples, Italy; Mediterranea Cardiocentro, 80122, Naples, Italy.